SWTX-143 free base · Synonyms: SWTX 143 · SWTX143

SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor.

For research use only. Not for human or veterinary use.

Target YAP

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

SWTX-143 structure

CAS No.: 2766575-48-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 898.00	BP-02257-25mg	In stock	Get quote
50 mg	USD 1,328.00	BP-02257-50mg	In stock	Get quote
100 mg	USD 1,876.00	BP-02257-100mg	In stock	Get quote
250 mg	USD 3,280.00	BP-02257-250mg	In stock	Get quote
500 mg	Inquire	BP-02257-500mg	In stock	Inquire
1 g	Inquire	BP-02257-1g	In stock	Inquire

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Description

SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity.

Biological activity

SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms.

Identifiers

SMILES: O=C(C=C)NC1CC2=C(N)C=CC=C2N(C3=CC=C(C(F)(F)F)C=C3)C1
InChIKey: YZNSUDZUJLMKNI-UHFFFAOYSA-N

Specifications

MW (average): 361.3609
Formula: C₁₉H₁₈F₃N₃O
CAS No.: 2766575-48-6
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 125 mg/mL

Documents

References

[1]. Hanne Hillen, et al. A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models. Mol Cancer Ther. 2023 Sep 23.

Same target

Search YAP

Same research area

Search Cancer