FX-909 free base · Synonyms: FX 909 · FX909

FX-909 is a covalent peroxisome proliferator-activated receptor gamma inverse agonist.

For research use only. Not for human or veterinary use.

Target PPAR

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

FX-909 structure

CAS No.: 2924573-90-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 700.00	BP-02247-25mg	In stock	Get quote
50 mg	USD 950.00	BP-02247-50mg	In stock	Get quote
100 mg	USD 1,400.00	BP-02247-100mg	In stock	Get quote
200 mg	USD 1,900.00	BP-02247-200mg	In stock	Get quote
500 mg	USD 2,800.00	BP-02247-500mg	In stock	Get quote
1 g	USD 4,550.00	BP-02247-1g	In stock	Get quote

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Description

FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist. FX-909 can be used for the research of cancer.

Biological activity

FX-909 (0.03-1 mg/kg; BID for 21 days) shows anticancer effects in UMUC9 UC xenograft mouse model

Identifiers

SMILES: FC1=C2C(NC(C3=C(S(C)(=O)=O)C=CC(C#N)=C3)=CC2=O)=CC(F)=C1
InChIKey: RBUBBZVQPHSZEZ-UHFFFAOYSA-N

Specifications

MW (average): 360.3350
Formula: C₁₇H₁₀F₂N₂O₃S
CAS No.: 2924573-90-8
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Mertz J A, et al. Development of a surrogate tissue pharmacodynamic (PD) assay for clinical use with FX-909, a novel inhibitor of the urothelial luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG). Cancer Research, 2023, 83(7_Supplement): 2802-2802.

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