MTX-531 free base · Synonyms: MTX 531 · MTX531

MTX-531 is a potent and selective inhibitor of EGFR.

For research use only. Not for human or veterinary use.

Target EGFR PI3K PPAR

Research area Cancer

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Data Sheet SDS COA

MTX-531 structure

CAS No.: 2791417-66-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 785.00	BP-00923-100mg	In stock	Get quote
250 mg	USD 1,385.00	BP-00923-250mg	In stock	Get quote
500 mg	USD 2,280.00	BP-00923-500mg	In stock	Get quote
1 g	Inquire	BP-00923-1g	In stock	Inquire

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Description

MTX-531 is a potent and selective inhibitor of EGFR and PI3K, with IC50s of 14.7 nM and 1.1-233 nM (differ in subtype). MTX-531 can also act as a weak agonist of PPARγ, with the EC50 of 3.4 μM in 293H cells .

Biological activity

MTX-531 is a first-in-class, potent and selective inhibitor of EGFR and PI3K, with IC50s of 14.7 nM and 1.1-233 nM (differ in subtype). MTX-531 can also act as a weak agonist of PPARγ, with the EC50 of 3.4 μM in 293H cells. MTX-531 inhibits EGFR and PI3K-mTOR signaling and tumor growth in the HNSCC PDX model.

Identifiers

SMILES: ClC1=C(NS(=O)(C)=O)C=C(C2=CC3=C(N=CN=C3N[C@@H](C4=CC=CC=C4)C)C=C2)C=N1
InChIKey: LPJIZDSOUGHTNB-CQSZACIVSA-N

Specifications

MW (average): 453.9450
Formula: C₂₂H₂₀ClN₅O₂S
CAS No.: 2791417-66-6
Physical state: Solid
Color: off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 2-8 ℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Christopher E Whitehead, et al. A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance. Nat Cancer. 2024 Jul 11.

Same target

Search EGFR

Same research area

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