BAY-4931 free base · Synonyms: BAY 4931 · BAY4931

BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist.

For research use only. Not for human or veterinary use.

Target PPAR

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

BAY-4931 structure

CAS No.: 423150-91-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 600.00	BP-02242-250mg	In stock	Get quote
500 mg	USD 1,085.00	BP-02242-500mg	In stock	Get quote
1 g	USD 1,698.00	BP-02242-1g	In stock	Get quote
2 g	USD 2,886.00	BP-02242-2g	In stock	Get quote

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Description

BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM.

Biological activity

In Vitro BAY-4931 (0-10 μM; 7 days) inhibits UM-UC-9 proliferation with an IC50 of 3.4 nM. BAY-4931 only inhibits CYP2C8 in CYP inhibition test.

Identifiers

SMILES: O=C(NC1=CC=C(OC(C2=CC=C(CC)C=C2)=N3)C3=C1)C4=CC([N+]([O-])=O)=CC=C4Cl
InChIKey: WFEBALYYDASKIV-UHFFFAOYSA-N

Specifications

MW (average): 421.8330
Formula: C₂₂H₁₆ClN₃O₄
CAS No.: 423150-91-8
Physical state: Solid
Color: Light yellow to light brown
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 125 mg/mL

Documents

References

[1]. Orsi DL, et al. Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069. J Med Chem. 2022 Nov 10;65(21):14843-14863.

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