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Ochnaflavone free base

Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2.

For research use only. Not for human or veterinary use.

Target Phospholipase
Research area Inflammation/Immunology
Purity >98% Stock Inquire

Ochnaflavone structure

CAS No.: 50276-96-5

Download structure (.mol)

Pack sizes & pricing

Size Price SKU Stock
1 mg USD 580.00 BP-02207-1mg In stock Get quote
5 mg USD 1,480.00 BP-02207-5mg In stock Get quote
10 mg USD 2,360.00 BP-02207-10mg In stock Get quote
25 mg USD 4,700.00 BP-02207-25mg In stock Get quote

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Description

Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC50 of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC50 of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases[1].

Identifiers

SMILES
O=C1C=C(C2=CC=C(OC3=CC(C4=CC(C5=C(O)C=C(O)C=C5O4)=O)=CC=C3O)C=C2)OC6=CC(O)=CC(O)=C16
InChIKey
NNPGECDACGBKDH-UHFFFAOYSA-N

Specifications

MW (average)
538.4579
Formula
C30H18O10
CAS No.
50276-96-5
Physical state
Solid
Color
Yellow to brown
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage
Powder 4°C, protect from light; In solvent -20°C, 1 month;

Solubility

soluble in DMSO

References

[1]. Moon TC, et al. Ochnaflavone, naturally occurring biflavonoid, inhibits phospholipase A2 dependent phosphatidylethanolamine degradation in a CCl4-induced rat liver microsome. Biol Pharm Bull. 2006 Dec;29(12):2359-61.

Same research area

Search Inflammation/Immunology