STX-478 free base · Synonyms: STX-478-101 | LY4064809

STX-478 is an oral CNS-penetrant allosteric mutant-selective PI3Kα inhibitor.

For research use only. Not for human or veterinary use.

Target PI3K

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

STX-478 structure

CAS No.: 2883540-92-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 729.00	BP-02252-100mg	In stock	Get quote
250 mg	USD 1,150.00	BP-02252-250mg	In stock	Get quote
500 mg	USD 1,650.00	BP-02252-500mg	In stock	Get quote
1 g	USD 2,450.00	BP-02252-1g	In stock	Get quote
2 g	USD 3,600.00	BP-02252-2g	In stock	Get quote
5 g	Inquire	BP-02252-5g	In stock	Inquire

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Description

STX-478 (compound 80) is an oral CNS-penetrant allosteric mutant-selective PI3Kα inhibitor. STX-478 shows robust and durable tumor regression and can be used in cancer research.

Biological activity

STX-478 (0-10,000 nM; 1 h) demonstrates selectivity for MCF10A cells harboring the H1047R kinase-domain mutation STX-478 (30, 100 mg/kg; p.o.; single daily for 28 days) dose-dependently reduces tumor volume in a CAL-33 xenograft mice model

Identifiers

SMILES: NC1=NC=C(C=N1)NC(N[C@H](C2=C(C3=CC(F)=CC(F)=C3O2)C)C(F)(F)F)=O
InChIKey: LGPNQALKGDDVBD-CYBMUJFWSA-N

Specifications

MW (average): 401.2908
Formula: C₁₆H₁₂F₅N₅O₂
CAS No.: 2883540-92-7
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. JR David St Jean, et al. Urea derivatives which can be used to treat cancer. Patent WO2022265993A1.

Same target

Search PI3K

Same research area

Search Cancer