PD-173952 free base · Synonyms: PD 173952 · PD173952

PD173952 is a tyrosine kinases inhibitor.

For research use only. Not for human or veterinary use.

Target Src Bcr-Abl Apoptosis Wee1

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

PD-173952 structure

CAS No.: 305820-75-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 498.00	BP-02204-100mg	In stock	Get quote
250 mg	USD 995.00	BP-02204-250mg	In stock	Get quote
500 mg	USD 1,580.00	BP-02204-500mg	In stock	Get quote
1 g	USD 2,540.00	BP-02204-1g	In stock	Get quote
2 g	USD 3,990.00	BP-02204-2g	In stock	Get quote

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Description

PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2].

Biological activity

In Vitro PD173952 (0-1000 nM; 12 h) inhibits tyrosine phosphorylation of p210Bcr-Abl and CrkL in K562 cells in a concentration-dependent manner. PD173952 (0.5 μM; 1-4 days) inhibits K562 cell viability. PD173952 (0.5 μM; 24 and 48 h) induces apoptosis of K562 and MEG-01 cells.

Identifiers

SMILES: O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=CN=C(NC4=CC=C(N5CCOCC5)C=C4)N=C3N1C
InChIKey: XZEJMVDCQZRHLN-UHFFFAOYSA-N

Specifications

MW (average): 482.3620
Formula: C₂₄H₂₁Cl₂N₅O₂
CAS No.: 305820-75-1
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

Documents

References

[1]. Dorsey JF, et al. Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors. Leukemia. 2002 Sep;16(9):1589-95.

[2]. Wichapong K, et al. Application of docking and QM/MM-GBSA rescoring to screen for novel Myt1 kinase inhibitors. J Chem Inf Model. 2014 Mar 24;54(3):881-93.

Same target

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