tilivalline free base

Tilivalline is an enterotoxin that can be produced by Klebsiella oxytoca.

For research use only. Not for human or veterinary use.

Target Apoptosis

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

tilivalline structure

CAS No.: 80279-24-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 mg	USD 450.00	BP-00039-1mg	In stock	Get quote
5 mg	USD 1,580.00	BP-00039-5mg	In stock	Get quote
10 mg	Inquire	BP-00039-10mg	In stock	Inquire
25 mg	Inquire	BP-00039-25mg	In stock	Inquire

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Description

Tilivalline is an enterotoxin that can be produced by Klebsiella oxytoca. Tilivalline shows cytotoxicity against carcinoma cells. Tilivalline induces epithelial apoptosis. Tilivalline causes antibiotic-associated hemorrhagic colitis (AAHC).

Biological activity

Tilivalline is a cytotoxic molecule produced by acid-producing Klebsiella.

Identifiers

SMILES: O=C1N2[C@]([C@@H](NC=3C1=CC=CC3O)C=4C=5C(NC4)=CC=CC5)(CCC2)[H]
InChIKey: AJZNARCWDDMOPL-WMZOPIPTSA-N

Specifications

MW (average): 333.3838
Formula: C₂₀H₁₉N₃O₂
CAS No.: 80279-24-9
Physical state: Solid
Color: Pale Beige to Light Brown
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Documents

References

[1]. Hering NA, et al. Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment. Int J Mol Sci. 2019 Nov 8;20(22):5595.

[2]. von Tesmar A, et al. Biosynthesis of the Klebsiella oxytoca Pathogenicity Factor Tilivalline: Heterologous Expression, in Vitro Biosynthesis, and Inhibitor Development. ACS Chem Biol. 2018 Mar 16;13(3):812-819.

Same target

Search Apoptosis

Same research area

Search Inflammation/Immunology