BGB-116673 analog free base · Synonyms: BTK-inhibitor

BGB-116673 analog is an investigational BTK‐targeting chimeric degradation activation compound (CDAC) active against both wild‐type and mutant BTK.

For research use only. Not for human or veterinary use.

Target PROTACs Btk

Research area Cancer

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Data Sheet SDS COA

BGB-116673 analog structure

CAS No.: 2736508-94-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 458.00	BP-00998-100mg	In stock	Get quote
250 mg	USD 898.00	BP-00998-250mg	In stock	Get quote
500 mg	USD 1,897.00	BP-00998-500mg	In stock	Get quote
1 g	USD 2,697.00	BP-00998-1g	In stock	Get quote
2 g	Inquire	BP-00998-2g	In stock	Inquire
5 g	Inquire	BP-00998-5g	In stock	Inquire

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Description

BGB-116673 analog is an investigational BTK‐targeting chimeric degradation activation compound (CDAC) active against both wild‐type and mutant BTK.

Biological activity

BTK-IN-29 (compound 14) is an inhibitor of Btk.

Identifiers

SMILES: C[C@@H](NC(=O)C1=NC(=NO1)C(C)(C)C)C1=CC=C(C=C1C)C1=C2C=C(NC2=NC=N1)C1=CC=C(N=C1)N1CCN(CC2CCN(CC2)C2=CC=C(C=C2)C2CCC(=O)NC2=O)CC1
InChIKey: UZDXDTMDMLTEJR-XNAWBMTISA-N

Specifications

MW (average): 850.0216
Formula: C₄₈H₅₅N₁₁O₄
CAS No.: 2736508-94-2
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in Powder 4℃ 2 years; In solvent -20℃ 1 month;

Documents

References

[1]. Hexiang Wang, et al. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use. WO2021219070A1. 2021-11-04.

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