Oxyphenbutazone free base
Oxyphenbutazone is a Phenylbutazone metabolite, with anti-inflammatory effect.
For research use only. Not for human or veterinary use.
Oxyphenbutazone structure
CAS No.: 129-20-4
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 450.00 | BP-02167-100mg | In stock | Get quote |
| 250 mg | USD 880.00 | BP-02167-250mg | In stock | Get quote |
| 500 mg | USD 1,420.00 | BP-02167-500mg | In stock | Get quote |
| 1 g | USD 2,280.00 | BP-02167-1g | In stock | Get quote |
| 2 g | USD 3,600.00 | BP-02167-2g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
Oxyphenbutazone is a Phenylbutazone metabolite, with anti-inflammatory effect. Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis. In Vivo Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.).
Biological activity
In Vitro Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells[1]. Oxyphenbutazone (2.5-7.5 μM; 48 hours) co-treatment with (MTX, 0.25-1.0 μM) shows potential cytotoxicity against Hep3B cells. Oxyphenbutazone exhibits reparative effects in the hepatocytes.
Identifiers
- SMILES
-
O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=C(O)C=C3)C1=O - InChIKey
-
HFHZKZSRXITVMK-UHFFFAOYSA-N
Specifications
- MW (average)
- 324.3737
- Formula
- C19H20N2O3
- CAS No.
- 129-20-4
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO : 100 mg/mL