Clobutinol free base

Clobutinol is a compound that has anti-tussive effects.

For research use only. Not for human or veterinary use.

Target Potassium Channel

Research area Cardiovascular Disease Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

Clobutinol structure

CAS No.: 14860-49-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 1,700.00	BP-00041-50mg	In stock	Get quote
100 mg	USD 2,180.00	BP-00041-100mg	In stock	Get quote

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Description

Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research.

Biological activity

In Vitro Clobutinol (10 μM) significantly inhibits the voltage-gated outward current in hERG-expressing cells[1]. Clobutinol (0-1000 μM) inhibits the outward current in hERG transfected cells with an IC50 value of 1.9 μM In Vivo Clobutinol (1-20 mg/kg; i.v. once) has no obvious effect on the airway of guinea-pigs. Clobutinol (1 and 10 mg/kg; i.v. once) affects heart rate and mean blood pressure of guinea pigs

Identifiers

SMILES: ClC1=CC=C(C=C1)CC(O)(C)C(C)CN(C)C
InChIKey: KVHHQGIIZCJATJ-UHFFFAOYSA-N

Specifications

MW (average): 255.7840
Formula: C₁₄H₂₂ClNO
CAS No.: 14860-49-2
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Documents

References

[1]. Deisemann H, et al. Effects of common antitussive drugs on the hERG potassium channel current. J Cardiovasc Pharmacol. 2008 Dec;52(6):494-9.

[2]. Salonen RO. Comparison of the effects of two opioid antitussives, vadocaine hydrochloride, clobutinol and lidocaine on lung mechanics in guinea-pigs. Arzneimittelforschung. 1988 Apr;38(4A):609-12.

[3]. Takahara A, Set al. Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031. J Cardiovasc Pharmacol. 2009 Dec;54(6):552-9.

Same target

Search Potassium Channel

Same research area

Search Cardiovascular Disease