RMC-0331 free base · Synonyms: RM-023

RMC-0331 is a potent, selective and orally bioavailable SOS1 inhibitor.

For research use only. Not for human or veterinary use.

Target SHP2 SOS1 Ras

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

RMC-0331 structure

CAS No.: 2488788-52-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 550.00	BP-02024-25mg	In stock	Get quote
50 mg	USD 850.00	BP-02024-50mg	In stock	Get quote
100 mg	USD 1,250.00	BP-02024-100mg	In stock	Get quote
250 mg	USD 1,750.00	BP-02024-250mg	In stock	Get quote
500 mg	Inquire	BP-02024-500mg	In stock	Inquire
1 g	Inquire	BP-02024-1g	In stock	Inquire

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Description

RMC-0331 is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.

Biological activity

In Vitro RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro. In Vivo RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models.

Identifiers

SMILES: COC1(C(N2CC3=NC(Cl)=NC(N[C@@H](C4=CC(C(F)(F)F)=CC(N)=C4)C)=C3C2)=O)CCOCC1
InChIKey: HOBOGRTXXDLZIB-GFCCVEGCSA-N

Specifications

MW (average): 499.9140
Formula: C₂₂H₂₅ClF₃N₅O₃
CAS No.: 2488788-52-7
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 125 mg/mL

Documents

References

[1]. Andreas Buckl, et al. Discovery of a Potent, Selective and Orally Bioavailable SOS1 Inhibitor, RMC-0331 (RM-023), an in vivo Tool Compound that Blocks RAS Activation via Disruption of the RAS-SOS1 Interaction.

Same target

Search SHP2

Same research area

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