RMC-4630 free base · Synonyms: SHP2-IN-7 | Vociprotafib

RMC-4630 is a potent and selective inhibitor of SHP2, a central node in the RAS signaling pathway.

For research use only. Not for human or veterinary use.

Target SHP2 Phosphatase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

RMC-4630 structure

CAS No.: 2172652-48-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 385.00	BP-01983-100mg	In stock	Get quote
250 mg	USD 735.00	BP-01983-250mg	In stock	Get quote
500 mg	USD 1,250.00	BP-01983-500mg	In stock	Get quote
1 g	USD 1,980.00	BP-01983-1g	In stock	Get quote
5 g	Inquire	BP-01983-5g	Inquire	Inquire

Custom Size Bulk Inquiry

Description

RMC-4630 is a potent and selective inhibitor of SHP2, a central node in the RAS signaling pathway.

Biological activity

In Vivo Vociprotafib delays and/or reduces tumor regrowth in mice upon cessation of treatment. Vociprotafib is effective at inhibiting tumor growth in a PDX model that has become resistant to Osimertinib via amplification of c-MET.

Identifiers

SMILES: OCC1=NC(SC2=C(Cl)C(N)=NC=C2)=C(C)N=C1N(CC3)CCC43[C@H](N)[C@H](C)OC4
InChIKey: HISJAYUQVHMWTA-BLLLJJGKSA-N

Specifications

MW (average): 450.9850
Formula: C₂₀H₂₇ClN₆O₂S
CAS No.: 2172652-48-9
Physical state: Solid
Color: Off-white to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 50 mg/mL

Documents

References

[1]. WO2018013597

[2]. Ou S I, et al. A12 the SHP2 inhibitor RMC-4630 in patients with KRAS-mutant non-small cell lung cancer: preliminary evaluation of a first-in-man phase 1 clinical trial[J]. Journal of Thoracic Oncology, 2020, 15(2): S15-S16.

[3]. Smith J A, et al. SHP2 inhibition as the backbone of targeted therapy combinations for the treatment of cancers driven by oncogenic mutations in the RAS pathway[J]. Cancer Research, 2020, 80(16_Supplement): 1943-1943.

Same target

Search SHP2

Same research area

Search Cancer