GDC-6036 other · Synonyms: Divarasib

GDC-6036 is an oral covalently mutated KRAS G12C inhibitor.

For research use only. Not for human or veterinary use.

Target Ras

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

GDC-6036 structure

CAS No.: 2417987-45-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 520.00	BP-02013A-100mg	In stock	Get quote
250 mg	USD 880.00	BP-02013A-250mg	In stock	Get quote
500 mg	USD 1,280.00	BP-02013A-500mg	In stock	Get quote
1 g	USD 1,850.00	BP-02013A-1g	In stock	Get quote
2 g	Inquire	BP-02013A-2g	In stock	Inquire

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Description

GDC-6036 (compound 17A) is an oral covalently mutated KRAS G12C inhibitor with IC50<0.01 μM against K-Ras G12C.

Biological activity

GDC-6036 (compound 17A) is an oral covalently mutated KRAS G12C inhibitor with IC50<0.01 μM against K-Ras G12C. The EC50 of GDC-6036 in K-Ras G12C-alkylated HCC1171 cells was 2 nM.

Identifiers

SMILES: C=CC(N1C[C@H](C)N(C2=C3C=C(Cl)[C@@]([C@@]4=C(C(F)(F)F)C(C)=CC(N)=N4)=C(F)C3=NC(OC[C@H]5N(C)CCC5)=N2)CC1)=O
InChIKey: ZRBPIAWWRPFDPY-IRXDYDNUSA-N

Specifications

MW (average): 622.0570
Formula: C₂₉H₃₂ClF₄N₇O₂
CAS No.: 2417987-45-0
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 100 mg/mL

Documents

References

[1]. Sushant Malhotra, et al. Fused ring compounds. WO2020097537A2.

Same target

Search Ras

Same research area

Search Cancer