ARS-1323-alkyne free base

ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.

For research use only. Not for human or veterinary use.

Target Ras

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

ARS-1323-alkyne structure

CAS No.: 2436544-27-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 520.00	BP-02017-10mg	In stock	Get quote
25 mg	USD 780.00	BP-02017-25mg	In stock	Get quote
50 mg	USD 1,120.00	BP-02017-50mg	In stock	Get quote
100 mg	USD 1,520.00	BP-02017-100mg	In stock	Get quote
250 mg	USD 1,980.00	BP-02017-250mg	In stock	Get quote
500 mg	Inquire	BP-02017-500mg	In stock	Inquire
1 g	Inquire	BP-02017-1g	In stock	Inquire

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Description

ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.

Biological activity

In Vitro ARS-1323-alkyne (10 μM) visualizes covalent modification of KRAS G12C in H358 and MIA PaCa-2 cells by electrophoretic mobility shift assay (EMSA) and click chemistry (in conjunction with TAMRA-N3) and quantitatively measures inhibitor binding efficiency to the target.

Identifiers

SMILES: O=C(C=C)N1CCN(C2=NC(NCCC(N(C)CC#C)=O)=NC3=C(F)C(C4=C(O)C=CC=C4F)=C(Cl)C=C23)CC1
InChIKey: FCCFZQSNDSLLMI-UHFFFAOYSA-N

Specifications

MW (average): 569.0020
Formula: C₂₈H₂₇ClF₂N₆O₃
CAS No.: 2436544-27-1
Physical state: Solid
Color: Off-white to light brown
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450.

Same target

Search Ras

Same research area

Search Cancer