K-Ras G12C-IN-4 free base

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C.

For research use only. Not for human or veterinary use.

Target Ras

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

K-Ras G12C-IN-4 structure

CAS No.: 2376328-55-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 460.00	BP-02004-50mg	In stock	Get quote
100 mg	USD 736.00	BP-02004-100mg	In stock	Get quote
250 mg	USD 1,160.00	BP-02004-250mg	In stock	Get quote
500 mg	USD 1,680.00	BP-02004-500mg	In stock	Get quote
1 g	Inquire	BP-02004-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C.

Biological activity

In Vitro K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells.

Identifiers

SMILES: COC1=CC=CC2=C1CCN(C(C3=C(N(C4=C3C=C(C=C4C)Cl)CC(NC5CN(C(C=C)=O)C5)=O)C6CC6)=O)C2
InChIKey: JESBUJUEMLEHDQ-UHFFFAOYSA-N

Specifications

MW (average): 561.0710
Formula: C₃₁H₃₃ClN₄O₄
CAS No.: 2376328-55-9
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 60 mg/mL (111.35 mM; Need ultrasonic(<60℃); hygroscopic DMSO has a significant impact on product solubility, please use newly opened DMSO)

Documents

References

[1]. Shin Y, et al. Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. ACS Med Chem Lett. 2019 Aug 20;10(9):1302-1308.

Same target

Search Ras

Same research area

Search Cancer