ARS-1630 free base · Synonyms: ARS-1630 (R enantiomer)

ARS-1630, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.

For research use only. Not for human or veterinary use.

Target Ras

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

ARS-1630 structure

CAS No.: 1698055-86-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 420.00	BP-01922-500mg	In stock	Get quote
1 g	USD 920.00	BP-01922-1g	In stock	Get quote
2 g	Inquire	BP-01922-2g	In stock	Inquire
5 g	Inquire	BP-01922-5g	In stock	Inquire
10 g	Inquire	BP-01922-10g	In stock	Inquire

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Description

ARS-1630, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.

Biological activity

In Vitro KRASG12C is recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP is restricted only to the GDP-bound state. This strategy proves feasible for inhibiting mutant KRAS in vitro.

Identifiers

SMILES: OC1=C(C(F)=CC=C1)C1=C(F)C2=NC=NC(N3CCN(CC3)C(=O)C=C)=C2C=C1Cl
InChIKey: ZRPZPNYZFSJUPA-UHFFFAOYSA-N

Specifications

MW (average): 430.8350
Formula: C₂₁H₁₇ClF₂N₄O₂
CAS No.: 1698055-86-5
Physical state: Solid
Color: white to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Liansheng Li, et al. Inhibitors of kras g12c. WO 2015054572 A1.

[2]. Janes MR, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018 Jan 25;172(3):578-589.e17.

Same target

Search Ras

Same research area

Search Cancer