M2N12 free base

M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase inhibitor.

For research use only. Not for human or veterinary use.

Target CDK

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

M2N12 structure

CAS No.: 2376577-06-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 460.00	BP-02005-50mg	In stock	Get quote
100 mg	USD 670.00	BP-02005-100mg	In stock	Get quote
250 mg	USD 1,080.00	BP-02005-250mg	In stock	Get quote
500 mg	USD 1,580.00	BP-02005-500mg	In stock	Get quote
1 g	Inquire	BP-02005-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09 μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of 0.53 μM and 1.39 μM, respectively. M2N12 has anti-tumor activity and can be used for cancer research.

Biological activity

M2N12 (0-20 μM; 72 hours) has cytotoxic activity against five tumor cell lines and a normal cell line including A-549, MDA-MB-231, KB, KB-VIN, MCF-7 and HBE (IC50=3.92 μM, 4.63 μM, 5.05 μM, 6.81 μM, 4.71 μM and 6.00 μM, respectively)

Identifiers

SMILES: O=C1C(Cl)=C(C(C2=NC=CC=C12)=O)NCC3=CN(CC4=CC=C(C)C=C4)N=N3
InChIKey: BDBIMDYALUJAPR-UHFFFAOYSA-N

Specifications

MW (average): 393.8260
Formula: C₂₀H₁₆ClN₅O₂
CAS No.: 2376577-06-7
Physical state: Solid
Color: brown to red
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 11.11 mg/mL

Documents

References

[1]. Jing L, et al. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur J Med Chem. 2019 Sep 14;183:111696.

Same target

Search CDK

Same research area

Search Cancer