CDK2-IN-73 free base · Synonyms: CDK2-IN-4

CDK2-IN-4 is a potent and selective CDK2 inhibitor.

For research use only. Not for human or veterinary use.

Target CDK

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

CDK2-IN-73 structure

CAS No.: 2079895-42-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 485.00	BP-01966-100mg	In stock	Get quote
250 mg	USD 885.00	BP-01966-250mg	In stock	Get quote
500 mg	USD 1,385.00	BP-01966-500mg	In stock	Get quote
1 g	USD 1,985.00	BP-01966-1g	In stock	Get quote
5 g	Inquire	BP-01966-5g	Inquire	Inquire

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Description

CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A.

Biological activity

In Vitro CDK2-IN-4 (compound 73) demonstrates appreciable nanomolar potency versus CDK2 in isolated kinase assays, the maximal concentration tested in cellular assays (30 μM) had no or limited effects on the growth of cells.

Identifiers

SMILES: O=S(C1=CC=C(C=C1)NC2=NC3=NC=NC3=C(C4=CC(C5=CC=CC=C5)=CC=C4)N2)(N)=O
InChIKey: FUGRWXRQJGJIER-UHFFFAOYSA-N

Specifications

MW (average): 442.4930
Formula: C₂₃H₁₈N₆O₂S
CAS No.: 2079895-42-2
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767.

Same target

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Same research area

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