GSK-3484862 free base · Synonyms: GSK 3484862 · GSK3484862

GSK-3484862 is a non-covalent inhibitor.

For research use only. Not for human or veterinary use.

Target DNA Methyltransferase Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

GSK-3484862 structure

CAS No.: 2170136-65-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 550.00	BP-01346-100mg	In stock	Get quote
250 mg	USD 900.00	BP-01346-250mg	In stock	Get quote
500 mg	USD 1,250.00	BP-01346-500mg	Inquire	Get quote
1 g	USD 1,850.00	BP-01346-1g	In stock	Get quote
5 g	Inquire	BP-01346-5g	In stock	Inquire
10 g	Inquire	BP-01346-10g	In stock	Inquire

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Description

GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity.

Biological activity

GSK-3484862 is a non-covalent inhibitor for Dnmt1. GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates global demethylation in murine embryonic stem cells.

Identifiers

SMILES: O=C(N)[C@H](SC1=NC(N(C)C)=C(C#N)C(CC)=C1C#N)C2=CC=CC=C2
InChIKey: KIEQQZZDWUNUQK-MRXNPFEDSA-N

Specifications

MW (average): 365.4520
Formula: C₁₉H₁₉N₅OS
CAS No.: 2170136-65-7
Physical state: Solid
Color: light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

In vitro: DMSO : 20 mg/mL

Documents

References

[1]. Azevedo Portilho N, et al. The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells. Epigenetics Chromatin. 2021;14(1):56. Published 2021 Dec 15.

[2]. Liu Y, et al. DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma. Mol Cancer. 2024;23(1):104. Published 2024 May 16.

[3]. Zhuang X, et al. Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis[J]. BioRxiv, 2024: 2024.06. 23.600305.

[4]. Chen Q, et al. GSK-3484862, a DNMT1 degrader, promotes DNMT3B expression in lung cancer cells. NAR Cancer. 2025;7(2):zcaf018. Published 2025 May 27.

Same target

Search DNA Methyltransferase

Same research area

Search Cancer