NST-628 free base · Synonyms: NST 628 · NST628

NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation.

For research use only. Not for human or veterinary use.

Target Molecular Glues Raf MEK

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

NST-628 structure

CAS No.: 3002056-30-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 528.00	BP-00092-100mg	In stock	Get quote
250 mg	USD 828.00	BP-00092-250mg	In stock	Get quote
500 mg	USD 1,248.00	BP-00092-500mg	In stock	Get quote
1 g	USD 1,758.00	BP-00092-1g	In stock	Get quote

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Description

Biological activity

NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway. NST-628 inhibits RAS- and RAF-driven cancers and demonstrated potent inhibition in mutant KRAS, NRAS, BRAF class II/III, and NF1-mutant tumors.

Identifiers

SMILES: FC1=C(OC2=CC=C(C(C)=C(CC3=C(F)C(NS(NC)(=O)=O)=NC=C3)C(O4)=O)C4=C2)N=CC=C1
InChIKey: YQSZJOABXRROQR-UHFFFAOYSA-N

Specifications

MW (average): 488.4640
Formula: C₂₂H₁₈F₂N₄O₅S
CAS No.: 3002056-30-3
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Ryan M B, et al. Abstract ND10: NST-628 is a novel, potent, fully brain-penetrant MAPK pathway molecular glue that inhibits RAS-and RAF-driven cancers[J]. Cancer Research, 2024, 84(7_Supplement): ND10-ND10.

[2]. Meagan B et al. The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov 2024.

Same target

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Same research area

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