NST-628 free base · Synonyms: NST 628 · NST628

NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation.

For research use only. Not for human or veterinary use.

Target Molecular Glues Raf MEK

Research area Cancer

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Data Sheet SDS COA

NST-628 structure

CAS No.: 3002056-30-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 528.00	BP-00092-100mg	In stock	Get quote
250 mg	USD 828.00	BP-00092-250mg	In stock	Get quote
500 mg	USD 1,248.00	BP-00092-500mg	In stock	Get quote
1 g	USD 1,758.00	BP-00092-1g	In stock	Get quote

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Description

Biological activity

NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway. NST-628 inhibits RAS- and RAF-driven cancers and demonstrated potent inhibition in mutant KRAS, NRAS, BRAF class II/III, and NF1-mutant tumors.

Identifiers

SMILES: FC1=C(OC2=CC=C(C(C)=C(CC3=C(F)C(NS(NC)(=O)=O)=NC=C3)C(O4)=O)C4=C2)N=CC=C1
InChIKey: YQSZJOABXRROQR-UHFFFAOYSA-N

Specifications

MW (average): 488.4640
Formula: C₂₂H₁₈F₂N₄O₅S
CAS No.: 3002056-30-3
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Ryan M B, et al. Abstract ND10: NST-628 is a novel, potent, fully brain-penetrant MAPK pathway molecular glue that inhibits RAS-and RAF-driven cancers[J]. Cancer Research, 2024, 84(7_Supplement): ND10-ND10.

[2]. Meagan B et al. The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov 2024.

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Same research area

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