PROTAC AR Degrader-5 free base

PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC50 value of 49 nM.

For research use only. Not for human or veterinary use.

Target PROTACs Androgen Receptor

Research area Metabolic Disease

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Data Sheet SDS COA

PROTAC AR Degrader-5 structure

CAS No.: 2703021-51-4

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Description

PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC50 value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration .

Biological activity

In Vivo PROTAC AR Degrader-5 (compound A46) (100, 200, 400, 800 µg + 12 µg TP; Skin application; daily for 21 days) inhibits sebaceous plaque in golden hamster[1]. PROTAC AR Degrader-5 (5, 10, 30 mg/ml +DHT 30 mpk; 150 µL; Skin application; 2 times a day for 17 days) induces hair regeneration in C57BL/6N mice

Identifiers

SMILES: S=C1N(C2=C(C(C(F)(F)F)=C(C=C2)C#N)F)C(C(C)(N1C3=CN=C(C4=CC=C(C=C4)OCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)C=C3)C)=O
InChIKey: HEIBMKWAJBMSPY-VTYXGMTLSA-N

Specifications

MW (average): 1043.1580
Formula: C₅₂H₅₄F₄N₈O₇S₂
CAS No.: 2703021-51-4
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Solubility

Soluble in DMSO

Documents

References

[1]. YouZhi Tong, et al. Bifunctional compound, preparation method therefor, and use thereof. WO2021180160A1.

Same target

Search PROTACs

Same research area

Search Metabolic Disease