dTAGV-1 hydrochloride salt form · hydrochloride · Parent dTAGV-1

dTAGV-1 hydrochloride is a selective FKBP12 F36V PORTAC degrader.

For research use only. Not for human or veterinary use.

Target PROTACs FKBP

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

dTAGV-1 hydrochloride structure

CAS No.: 2624313-16-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 558.00	BP-00771A-10mg	In stock	Get quote
25 mg	USD 1,198.00	BP-00771A-25mg	In stock	Get quote
50 mg	USD 1,989.00	BP-00771A-50mg	In stock	Get quote
100 mg	USD 3,798.00	BP-00771A-100mg	In stock	Get quote
250 mg	Inquire	BP-00771A-250mg	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

dTAGV-1 hydrochloride is a selective FKBP12 F36V PORTAC degrader. dTAGV-1 hydrochloride induces rapid degradation of FKBP12 F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduced proliferative capacity of cancer cells, and decreased levels of target proteins. dTAGV-1 hydrochloride is applicable to functional validation studies of cancer and undegradable oncoproteins .

Biological activity

dTAGV-1 hydrochloride is the hydrochloride form of dTAGV-1 that is a small molecule degrader of FKBP12.

Identifiers

SMILES: [C@@H](OC(=O)[C@H]1N(C([C@@H](CC)C2=CC(OC)=C(OC)C(OC)=C2)=O)CCCC1)(CCC3=CC(OC)=C(OC)C=C3)C4=C(OCC(NCCCCCCC(N[C@H](C(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C=7SC=NC7C)=O)C[C@@H](O)C5)[C@](C)(C)C)=O)=O)C=CC=C4.Cl
InChIKey: WZEDGWVEEAWMSD-LNVAYBNASA-N

Specifications

MW (average): 1284.0000
Formula: C₆₈H₉₁ClN₆O₁₄S
CAS No.: 2624313-16-0
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Nabet B, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nature communications. 2020 Sep 18;11(1):4687.

[2]. Zhu J, et al. FeaSion decodes the regulatory landscape and functional diversity of RNA polymerase II CTD phosphorylation. Science advances. 2025 Nov 28;11(48):eadz2345.

[3]. Prindle V, et al. Synthetic lethality of mRNA quality control complexes in cancer. Nature. 2025 Feb;638(8052):1095-1103.

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