Nampt-IN-10 TFA salt form · salt · Parent Nampt-IN-10 TFA

Nampt-IN-10 TFA is a Nicotinamide Phosphoribosyltransferase inhibitor.

For research use only. Not for human or veterinary use.

Target NAMPT

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Nampt-IN-10 TFA structure

CAS No.: 2567724-20-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 380.00	BP-02420A-25mg	In stock	Get quote
50 mg	USD 610.00	BP-02420A-50mg	In stock	Get quote
100 mg	USD 970.00	BP-02420A-100mg	In stock	Get quote
250 mg	USD 1,945.00	BP-02420A-250mg	In stock	Get quote
500 mg	USD 3,110.00	BP-02420A-500mg	In stock	Get quote
1 g	USD 4,980.00	BP-02420A-1g	In stock	Get quote
2 g	Inquire	BP-02420A-2g	In stock	Inquire

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Description

Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs .

Biological activity

In Vitro Nampt-IN-10 TFA (0-1 μM; 72 h) shows cellular potency to A2780, CORL23, and c-Kit and HER2 expressing cell lines.

Identifiers

SMILES: FC(C=C1NC([C@@H]2[C@@H](C3=CN=CC=C3)C2)=O)=C(C=C1)CNC(C4=CC=C(N5CCNCC5)C=C4)=O.OC(C(F)(F)F)=O.[x]

Specifications

MW (average): 603.6077
Formula: C₃₀H₃₃F₄N₅O₄
CAS No.: 2567724-20-1
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: 4°C, sealed storage, away from moisture

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1].Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

Same target

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BP-02125 KPT-9274 free base · >98%

Same research area

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