MRTX0902 free base · Synonyms: MRTX-0902 · MRTX 0902
MRTX0902 is an effective SOS1 inhibitor.
For research use only. Not for human or veterinary use.
MRTX0902 structure
CAS No.: 2654743-22-1
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 450.00 | BP-02360-25mg | In stock | Get quote |
| 50 mg | USD 650.00 | BP-02360-50mg | In stock | Get quote |
| 100 mg | USD 900.00 | BP-02360-100mg | In stock | Get quote |
| 250 mg | USD 1,350.00 | BP-02360-250mg | In stock | Get quote |
| 500 mg | USD 2,150.00 | BP-02360-500mg | In stock | Get quote |
| 1 g | Inquire | BP-02360-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
MRTX0902 is an effective SOS1 inhibitor with an IC50 of 46 nM.
Biological activity
MRTX0902 is an oral brain penetrating SOS1:KRAS protein-protein interaction inhibitor with an IC50 of 46 nM. MRTX0902 displays high selectivity on SOS1 (Ki=2 nM) over SOS2 and EGFR (both Ki values >10,000 nM), MRTX0902 inhibits MKN1 cells with an IC50 value of 29 nM. MRTX0902 (25, 50 mg/kg; p.o.; twice daily; 25 d) shows anti-tumor effect in mouse model and results tumor regression.
Identifiers
- SMILES
-
C[C@H](C1=C(C(C#N)=CC=C1)C)NC2=NN=C(C)C3=C2C=C(N4CCOCC4)N=C3 - InChIKey
-
ILPWEAHQRAWJIU-OAHLLOKOSA-N
Specifications
- MW (average)
- 388.4656
- Formula
- C22H24N6O
- CAS No.
- 2654743-22-1
- Physical state
- Solid
- Color
- Light yellow to green yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
- In vitro
- DMSO 12.5 mg/mL