IHMT-PI3Kδ-372 free base · Synonyms: IHMT-PI3Kδ-372 R-isomer | IHMT-PI3K-372

IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor.

For research use only. Not for human or veterinary use.

Target PI3K

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

IHMT-PI3Kδ-372 structure

CAS No.: 2429889-62-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 480.00	BP-02016-100mg	In stock	Get quote
250 mg	USD 792.00	BP-02016-250mg	In stock	Get quote
500 mg	USD 1,148.00	BP-02016-500mg	In stock	Get quote
1 g	USD 1,680.00	BP-02016-1g	In stock	Get quote

Need another size or custom synthesis? Request a quote.

Description

IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research.

Identifiers

SMILES: O=C1N(C2CC2)C([C@H](N3N=C(C4=CC=C(OC)C(F)=C4)C5=C(N)N=CN=C53)CC)=NC6=C1C(F)=CC=C6
InChIKey: HTUBTEAYSCSTIY-GOSISDBHSA-N

Specifications

MW (average): 503.5033
Formula: C₂₆H₂₃F₂N₇O₂
CAS No.: 2429889-62-1
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 12.5 mg/mL

Documents

References

[1]. Feng Li, et al. Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1 H-pyrazolo[3,4- d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3 H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63(22):13973-13993.

Same target

Search PI3K

Same research area

Search Inflammation/Immunology