PI 828 free base · Synonyms: PI-828 · PI828

PI-828 is a dual PI3K and casein kinase 2 inhibitor.

For research use only. Not for human or veterinary use.

Target PI3K Casein Kinase

Research area Cancer

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Data Sheet SDS COA

PI 828 structure

CAS No.: 942289-87-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 620.00	BP-01363-250mg	In stock	Get quote
500 mg	USD 980.00	BP-01363-500mg	In stock	Get quote
1 g	USD 1,600.00	BP-01363-1g	In stock	Get quote
2 g	USD 2,550.00	BP-01363-2g	In stock	Get quote
3 g	USD 3,080.00	BP-01363-3g	In stock	Get quote
5 g	USD 3,980.00	BP-01363-5g	In stock	Get quote

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Description

PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.

Biological activity

In Vitro PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells. PI-828 (0.78-3.12 µM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis.

Identifiers

SMILES: O=C1C=C(N2CCOCC2)OC3=C(C4=CC=C(N)C=C4)C=CC=C13
InChIKey: WUKMIBOGGXMBAC-UHFFFAOYSA-N

Specifications

MW (average): 322.3578
Formula: C₁₉H₁₈N₂O₃
CAS No.: 942289-87-4
Physical state: Solid
Color: white to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

Documents

References

[1]. Gharbi SI, et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 2007 May 15;404(1):15-21.

[2]. Kulkarni AA, et al. Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res. 2013 Dec 1;73(23):6987-97.

[3]. Zellefrow CD, et al. Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay. Radiat Res. 2012 Sep;178(3):150-9.

Same target

Search PI3K

Same research area

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