ACT-672125 free base · Synonyms: ACT 672125 · ACT672125

ACT-672125 is a potent CXCR3 antagonist.

For research use only. Not for human or veterinary use.

Target CXCR

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

ACT-672125 structure

CAS No.: 1449367-94-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 1,485.00	BP-02240-25mg	In stock	Get quote
50 mg	USD 1,827.00	BP-02240-50mg	In stock	Get quote
100 mg	USD 2,380.00	BP-02240-100mg	In stock	Get quote
250 mg	USD 2,990.00	BP-02240-250mg	In stock	Get quote
500 mg	Inquire	BP-02240-500mg	In stock	Inquire

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Description

ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with IC50 value of 18μM. ACT-672125 can be used for the research of autoimmune diseases.

Identifiers

SMILES: FC(F)(C1=NC(C2=NC3=CC=C(C4=NOC(C)=N4)C=C3N2)=C(N5C[C@H](N(CC5)C(CN6C(C)=NC(C)=N6)=O)C)S1)F
InChIKey: SXYUBRILLHMIAQ-GFCCVEGCSA-N

Specifications

MW (average): 586.5920
Formula: C₂₅H₂₅F₃N₁₀O₂S
CAS No.: 1449367-94-5
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: 250 mg/mL

Documents

References

[1]. Caroff E, et al. Design, Synthesis, and Pharmacological Evaluation of Benzimidazolo-thiazoles as Potent CXCR3 Antagonists with Therapeutic Potential in Autoimmune Diseases: Discovery of ACT-672125. J Med Chem. 2022 Sep 8;65(17):11533-11549.

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