AZD-5069 free base · Synonyms: AZD 5069 · AZD5069
AZD-5069 is a potent CXCR2 chemokine receptor antagonist.
For research use only. Not for human or veterinary use.
Target
CXCR
Purity >98%
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AZD-5069 structure
CAS No.: 878385-84-3
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 315.00 | BP-02095-50mg | In stock | Get quote |
| 100 mg | USD 504.00 | BP-02095-100mg | In stock | Get quote |
| 250 mg | USD 1,008.00 | BP-02095-250mg | In stock | Get quote |
| 500 mg | USD 1,610.00 | BP-02095-500mg | In stock | Get quote |
| 1 g | USD 2,580.00 | BP-02095-1g | In stock | Get quote |
| 2 g | USD 4,130.00 | BP-02095-2g | In stock | Get quote |
| 3 g | Inquire | BP-02095-3g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.
Biological activity
In Vitro AZD-5069 (Compound 2) acts as CXCR2 antagonist by inhibition of [125I]-IL-8 binding to human CXCR2 receptors and as inhibitor of GROα-induced Ca2+ flux in human neutrophils loaded with fluo-3 dye.
Identifiers
- SMILES
-
C[C@@H](OC1=CC(NS(=O)(=O)N2CCC2)=NC(SCC2=CC=CC(F)=C2F)=N1)[C@@H](O)CO - InChIKey
-
QZECRCLSIGFCIO-RISCZKNCSA-N
Specifications
- MW (average)
- 476.5180
- Formula
- C18H22F2N4O5S2
- CAS No.
- 878385-84-3
- Physical state
- Solid
- Color
- White to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
Documents
References
[1]. Norman P, et al. Evidence on the identity of the CXCR2 antagonist AZD-5069. Expert Opin Ther Pat. 2013 Jan;23(1):113-7.