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Orforglipron hemicalcium hydrate free base · Synonyms: LY3502970 hemicalcium hydrate | GLP-1 receptor agonist 1 hemicalcium hydrate

Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate) represents the hemicalcium hydrate form of the calcium salt of Orforglipron, an…

For research use only. Not for human or veterinary use.

Target GCGR
Research area Metabolic Disease Inflammation/Immunology
Purity >99.5% Stock Inquire
Data Sheet SDS COA

Orforglipron hemicalcium hydrate structure

CAS No.: 3008544-96-2

Download structure (.mol)

Pack sizes & pricing

Size Price SKU Stock
50 mg USD 580.00 BP-00335-50mg In stock Get quote
100 mg USD 750.00 BP-00335-100mg In stock Get quote
250 mg USD 1,380.00 BP-00335-250mg In stock Get quote
500 mg USD 2,380.00 BP-00335-500mg In stock Get quote
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Description

Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate) represents the hemicalcium hydrate form of the calcium salt of Orforglipron, an orally active agonist targeting the Glucagon-like peptide-1 receptor (GLP-1R). This compound has demonstrated efficacy in mitigating type 2 diabetes.

Biological activity

Orforglipron hemicalcium hydrate (0.94-4.8 nM in plasma concentration, i.v., or 0.05-0.1 mg/mL, i.g. for 5 days) suppresses food intake in a dose-dependent manner, promotes insulin secretion and blood glucose reduction in cynomolgus monkey model[1]. Orforglipron hemicalcium hydrate (0.05-1.35 mg/kg, i.g.) reaches Cmax 2 hours after administration at all doses, exhibits proportional ratio of increase in plasma drug exposure to dose increase, indicates a dose-dependent absorption in the gastrointestinal tract

Identifiers

SMILES
C[C@@H]1[C@](N2C3=CC=C([C@]4([H])CC(C)(OCC4)C)C=C3C=C2C(N5[C@H](C6=C(N7C(N(C8=CC=C(N(N=C9)C)C9=C8F)C=C7)=O)N(C%10=CC(C)=C(C(C)=C%10)F)N=C6CC5)C)=O)(C(N%11)=NOC%11=O)C1.[0.5].[Ca].O

Specifications

MW (average)
941.0490
Formula
C48H50CaF2N10O6
CAS No.
3008544-96-2
Physical state
Solid
Color
white to off-white
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage
Powder 4℃, sealed storage, away from moisture, protect from light, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro
DMSO : 25 mg/mL

Documents

References

[1]. Pyrazolopyridine derivative having glp-1 receptor agonist effect. WO2018056453A1

Same target

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Same research area

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