diABZI STING agonist-1 Tautomerism free base · Synonyms: diABZI STING agonist (Compound 3) | 2138299-33-7

diABZI STING agonist-1 Tautomerism is a selective stimulator of interferon genes receptor agonist.

For research use only. Not for human or veterinary use.

Target STING

Research area Inflammation/Immunology

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Data Sheet SDS COA

diABZI STING agonist-1 Tautomerism structure

CAS No.: 2138498-18-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 1,200.00	BP-02236-100mg	In stock	Get quote
250 mg	USD 1,800.00	BP-02236-250mg	In stock	Get quote
500 mg	USD 3,480.00	BP-02236-500mg	In stock	Get quote
1 g	Inquire	BP-02236-1g	In stock	Inquire
2 g	Inquire	BP-02236-2g	In stock	Inquire
5 g	Inquire	BP-02236-5g	In stock	Inquire

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Description

diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

Biological activity

In Vitro diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested. In Vivo diABZI STING agonist-1 (subcutaneous injection; 2.5 mg/kg) tautomerism induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo. diABZI STING agonist-1 (intravenous injection; 3 mg/kg) tautomerism exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (200 ng/mL). diABZI STING agonist-1 (intravenous injection; 1.5 mg/kg; 43 days) tautomerism results in significant tumour growth inhibition and significantly improves survival with 8 out of 10 mice remaining tumor free at the end of the study on day 43.

Identifiers

SMILES: O=C(N)C1=CC(N/C(N2C/C=C/CN3/C(NC4=C3C(OCCCN5CCOCC5)=CC(C(N)=O)=C4)=N/C(C6=CC(C)=NN6CC)=O)=N\C(C7=CC(C)=NN7CC)=O)=C2C(OC)=C1
InChIKey: JGLMVXWAHNTPRF-CMDGGOBGSA-N

Specifications

MW (average): 849.9372
Formula: C₄₂H₅₁N₁₃O₇
CAS No.: 2138498-18-5
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO, water

Documents

References

[1]. Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7.

Same research area

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