Trabodenoson free base · Synonyms: INO-8875
Trabodenoson, an adenosine mimetic, is a highly selective Adenosine A1 receptor agonist.
For research use only. Not for human or veterinary use.
Trabodenoson structure
CAS No.: 871108-05-3
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 380.00 | BP-02213-100mg | In stock | Get quote |
| 250 mg | USD 750.00 | BP-02213-250mg | In stock | Get quote |
| 500 mg | USD 1,200.00 | BP-02213-500mg | In stock | Get quote |
| 1 g | USD 1,950.00 | BP-02213-1g | In stock | Get quote |
| 2 g | USD 3,140.00 | BP-02213-2g | In stock | Get quote |
| 3 g | USD 3,750.00 | BP-02213-3g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
Trabodenoson (INO-8875), an adenosine mimetic, is a highly selective Adenosine A1 receptor agonist. Trabodenoson (INO-8875) is used in the study for Primary Open-Angle Glaucoma[1].
Biological activity
In Vitro Trabodenoson treatment significantly increaseS MMP-2 activity and MMP-14 abundance, while decreasing fibronectin and collagen IV expression. In Vivo Trabodenoson (6.0%), demonstrating an average IOP drop of 2.45 ± 0.38 mm Hg in young mice over 7 days (downregulation). Topical trabodenoson significantly upregulates nestin expression in the ONH of induced eyes compared with vehicle-treated no-induced eyes. Trabodenoson-treated eyes have significantly reduced optic nerve (ON) edema compared with vehicle-treated eyes. RGC counts are higher in Trabodenoson-treated eyes compared to vehicle (74% versus 47% of the contralateral eye).
Identifiers
- SMILES
-
O[C@H]1[C@@H](O[C@H](CO[N+]([O-])=O)[C@H]1O)N2C3=NC=NC(NC4CCCC4)=C3N=C2 - InChIKey
-
AQLVRTWKJDTWQQ-SDBHATRESA-N
Specifications
- MW (average)
- 380.3559
- Formula
- C15H20N6O6
- CAS No.
- 871108-05-3
- Physical state
- Solid
- Color
- White to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 year;
Solubility
soluble in DMSO