AZD-4635 free base · Synonyms: Imaradenant | HTL1071

Imaradenant is an oral A2AR antagonist.

For research use only. Not for human or veterinary use.

Target Adenosine Receptor

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

AZD-4635 structure

CAS No.: 1321514-06-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 480.00	BP-01868-500mg	In stock	Get quote
1 g	USD 780.00	BP-01868-1g	In stock	Get quote
5 g	Inquire	BP-01868-5g	In stock	Inquire
10 g	Inquire	BP-01868-10g	Inquire	Inquire

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Description

Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.

Biological activity

In Vitro In the presence of 0.1, 1 and 10 μM adenosine, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM, respectively.

Identifiers

SMILES: CC1=CC(=CC(Cl)=N1)C1=C(N=C(N)N=N1)C1=CC=C(F)C=C1
InChIKey: NCWQLHHDGDXIJN-UHFFFAOYSA-N

Specifications

MW (average): 315.7330
Formula: C₁₅H₁₁ClFN₅
CAS No.: 1321514-06-0
Physical state: Solid
Color: Off-white to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Jazayeri A, Andrews SP, Marshall FH. Structurally Enabled Discovery of Adenosine A(2A) Receptor Antagonists. Chem Rev. 2017 Jan 11;117(1):21-37. doi:10.1021/acs.chemrev.6b00119. Epub 2016 Jun 22. Review. PubMed PMID: 27333206.

[2]. Alexandra Borodovsky, et al. Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR Cancer Res. 2017, 77(13 Suppl):Abstract nr 5580.

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