Leucettine L41 free base
Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinases.
For research use only. Not for human or veterinary use.
Leucettine L41 structure
CAS No.: 1112978-84-3
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 610.00 | BP-02182-100mg | In stock | Get quote |
| 250 mg | USD 1,240.00 | BP-02182-250mg | In stock | Get quote |
| 500 mg | USD 1,970.00 | BP-02182-500mg | In stock | Get quote |
| 1 g | USD 3,150.00 | BP-02182-1g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) and CDC-like kinases (CLKs). Leucettine L41 can also inhibit GSK-3 singnaling. Leucettine L41 can inhibit cell apoptosis and ROS production. Leucettine L41 can promote β-cell cell cycle progression, cell proliferation and increase insulin secretion. Leucettine L41 can be used for the researches of neurological disease and metabolic disease, such as Alzheimer’s disease (AD) and diabetes .
Biological activity
In Vitro Leucettine L41 (0.01-100 μM) increases viability and proliferation in MIN6 cells. Leucettine L41 (5 μM, 24 h) increases cells in G2/M phase in MIN6 cells. Leucettine L41 (5 μM, 24 h) increases insulin and C-peptide production in MIN6 cells. Leucettine L41 improves insulin secretion in isolated mouse islets. In Vivo Leucettine L41 (0.4-4 μg, i.c.v.) prevents memory deficits and neurotoxicity in Aβ25-35-treated mice.
Identifiers
- SMILES
-
O=C1NC(NC2=CC=CC=C2)=N/C1=C\C3=CC=C(OCO4)C4=C3 - InChIKey
-
PGPHHJBZEGSUNE-JYRVWZFOSA-N
Specifications
- MW (average)
- 307.3034
- Formula
- C17H13N3O3
- CAS No.
- 1112978-84-3
- Physical state
- Solid
- Color
- Light yellow to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;
Solubility
soluble in DMSO