CDDO-3P-Im free base · Synonyms: CDDO-3P-Imidazolide

CDDO-3P-Im is an analogue of CDDO-Imidazolide.

For research use only. Not for human or veterinary use.

Target Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

CDDO-3P-Im structure

CAS No.: 1883650-95-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 498.00	BP-01943-500mg	In stock	Get quote
1 g	USD 880.00	BP-01943-1g	In stock	Get quote
2 g	Inquire	BP-01943-2g	In stock	Inquire
5 g	Inquire	BP-01943-5g	Inquire	Inquire

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Description

CDDO-3P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-3P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model. CDDO-3P-Im is a orally active necroptosis inhibitor that can be used for the research of ischemia/reperfusion (I/R).

Biological activity

In Vitro CDDO-3P-Im (30-100 nM; 4 days) induces differentiation of U937 cells at 30 nM. CDDO-3P-Im suppresses NO production in RAW264.7 cells with an IC50 of 4.3 nM. In Vivo CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies. CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo. CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.

Identifiers

SMILES: [H][C@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C=C2[C@@]3(C)C=C(C#N)C(=O)C(C)(C)C3CC[C@@]12C)C(=O)N1C=NC(=C1)C1=NC=CC=C1
InChIKey: NXUDOCUNEVFUGK-LWQNBPKTSA-N

Specifications

MW (average): 618.8075
Formula: C₃₉H₄₆N₄O₃
CAS No.: 1883650-95-0
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Cao M , et al. Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention. Pharmacol Res. 2015 Oct;100:135-47.

[2]. Yuanyuan Wang, et al. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors. Eur J Med Chem. 2020 Nov 21;113030.

Same target

Search Apoptosis

Same research area

Search Cancer