Rodatristat ethyl free base · Synonyms: KAR5585
Rodatristat ethyl is a first-in-class oral tryptophan hydroxylase 1 Inhibitor.
For research use only. Not for human or veterinary use.
Rodatristat ethyl structure
CAS No.: 1673571-51-1
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 5 mg | USD 680.00 | BP-01919-5mg | In stock | Get quote |
| 10 mg | USD 980.00 | BP-01919-10mg | In stock | Get quote |
| 25 mg | USD 1,780.00 | BP-01919-25mg | In stock | Get quote |
| 50 mg | USD 2,780.00 | BP-01919-50mg | In stock | Get quote |
| 100 mg | USD 3,780.00 | BP-01919-100mg | In stock | Get quote |
| 500 mg | Inquire | BP-01919-500mg | In stock | Inquire |
| 1 g | Inquire | BP-01919-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH).
Biological activity
In Vivo Rodatristat ethyl (100 or 200 mg/kg; oral administration; once daily; for 28 days; male Sprague-Dawley rats) treatment decreases erum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduces pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats with monocrotaline (MCT).
Identifiers
- SMILES
-
ClC1=CC(C2=CC=CC=C2)=C([C@@H](OC3=NC(N)=NC(N4CCC5(CN[C@H](C(OCC)=O)C5)CC4)=C3)C(F)(F)F)C=C1 - InChIKey
-
TZSZZENYCISATO-WIOPSUGQSA-N
Specifications
- MW (average)
- 590.0360
- Formula
- C29H31ClF3N5O3
- CAS No.
- 1673571-51-1
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Solubility
Soluble in DMSO : 100 mg/mL