Ulacamten free base · Synonyms: CK-4021586 | CK-586

CK-586 is an inhibitor of cardiac myosin used to treat obstructive hypertrophic cardiomyopathy.

For research use only. Not for human or veterinary use.

Target Myosin

Research area Cardiovascular Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Ulacamten structure

CAS No.: 2830607-59-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 550.00	BP-00963-100mg	In stock	Get quote
250 mg	USD 852.00	BP-00963-250mg	In stock	Get quote
500 mg	USD 1,252.00	BP-00963-500mg	In stock	Get quote
1 g	USD 1,752.00	BP-00963-1g	In stock	Get quote
5 g	Inquire	BP-00963-5g	Inquire	Inquire

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Description

CK-586(Ulacamten; CK-4021586) is an inhibitor of cardiac myosin used to treat obstructive hypertrophic cardiomyopathy (oHCM). It effectively reduces left ventricular outflow tract obstruction (LVOTO) in a dose-dependent manner.

Biological activity

In Vitro Ulacamten (5 μM) inhibits fractional shortening by >80% in electrically-paced adult rat ventricular cardiomyocytes without altering the calcium transient. In Vivo Ulacamten (2-15 mg/kg; p.o.; single dose) safely and dose-dependently ameliorates left ventricular outflow tract obstruction, reduces LV systolic function, and increases systolic LV chamber size in purpose-bred cats with naturally occurring obstructive hypertrophic cardiomyopathy, with the greatest effects observed at 6 hours post-dose. Ulacamten reduces cardiac fractional shortening in normal Sprague-Dawley rats in a dose- and concentration-dependent manner.

Identifiers

SMILES: C(N1C2(C(=O)N(CC1=O)[C@@H]3CC[C@@H](C)CC3)CN(C=O)C2)C4=CC(F)=C(F)C=C4
InChIKey: HLMGUFOCTBBSLK-KOMQPUFPSA-N

Specifications

MW (average): 405.4383
Formula: C₂₁H₂₅F₂N₃O₃
CAS No.: 2830607-59-3
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃ 2 years; -20℃ 3 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Rivas VN, et al. Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy. Sci Rep. 2024;14(1):12038. Published 2024 May 27.

[2]. Sarkar S S, et al. Preclinical characterization of CK-4021586, a new class of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy[J]. Biophysical Journal, 2023, 122(3): 122a.

Same research area

Search Cardiovascular Disease