AZD-7594 free base · Synonyms: Velsecorat

AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator.

For research use only. Not for human or veterinary use.

Target Glucocorticoid Receptor

Research area Inflammation/Immunology Endocrinology

Purity >98% Stock Inquire

Data Sheet SDS COA

AZD-7594 structure

CAS No.: 1196509-60-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 395.00	BP-01848-50mg	In stock	Get quote
100 mg	USD 608.00	BP-01848-100mg	In stock	Get quote
250 mg	USD 920.00	BP-01848-250mg	In stock	Get quote
500 mg	USD 1,380.00	BP-01848-500mg	In stock	Get quote
1 g	Inquire	BP-01848-1g	In stock	Inquire

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Description

AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM.

Biological activity

In Vitro AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. AZD7594 shows no effect on progesterone receptor, mineralocorticoid receptor, Androgen receptor, ERα or ERβ (IC50, > 10 μM). In Vivo AZD7594 has anti-inflammatory activity, and efficiently inhibits rat lung edema.

Identifiers

SMILES: C[C@H](NC(=O)C(C)(F)F)[C@H](OC1=CC2=C(C=C1)N(N=C2)C1=CC(=CC=C1)C(=O)N[C@@H]1CCOC1)C1=CC=C2OCCOC2=C1
InChIKey: ZZWJKLGCDHYVMB-BWGXUDETSA-N

Specifications

MW (average): 606.6165
Formula: C₃₂H₃₂F₂N₄O₆
CAS No.: 1196509-60-0
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Hemmerling M, et al. Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases. J Med Chem. 2017 Oct 26;60(20):8591-8605.

Same target

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Same research area

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