Stepronin free base

Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration).

For research use only. Not for human or veterinary use.

Target Chloride Channel

Research area Endocrinology

Purity >98% Stock Inquire

Data Sheet SDS COA

Stepronin structure

CAS No.: 72324-18-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 280.00	BP-00021-100mg	In stock	Get quote
250 mg	USD 560.00	BP-00021-250mg	In stock	Get quote
500 mg	USD 900.00	BP-00021-500mg	In stock	Get quote
1 g	USD 1,420.00	BP-00021-1g	In stock	Get quote
2 g	USD 2,300.00	BP-00021-2g	In stock	Get quote
3 g	USD 2,750.00	BP-00021-3g	In stock	Get quote
5 g	USD 3,670.00	BP-00021-5g	In stock	Get quote
10 g	Inquire	BP-00021-10g	In stock	Inquire

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Description

Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands.

Biological activity

In Vitro Stepronin (0.1-100 μM; 20 min) induces significant reductions in ISOP(Isoproterenol)-evoked SCC (short circuit current) value in a dose-dependent manner in canine tracheal epithelium. Stepronin (10-100 μM; 20 min) significantly inhibits the basal secretion and ISOP-evoked PD (potential difference) value in a dose-dependent manner in canine tracheal epithelium. Stepronin (100 μM; 20 min) significantly inhibits ISOP-induced [3H]-glycoconjugate secretion in submucosal glands.

Identifiers

SMILES: O=C(SC(C(=O)NCC(=O)O)C)C=1SC=CC1
InChIKey: JNYSEDHQJCOWQU-UHFFFAOYSA-N

Specifications

MW (average): 273.3290
Formula: C₁₀H₁₁NO₄S₂
CAS No.: 72324-18-6
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO : ≥ 250 mg/mL

Documents

References

[1]. Yamada K, et al. An expectorant, stepronin, reduces airway secretion in vitro. Respiration. 1994;61(1):42-7.

Same research area

Search Endocrinology