VT-1598 free base · Synonyms: VT 1598 · VT1598

VT-1598 is an orally active and selective fungal inhibitor targeting CYP51.

For research use only. Not for human or veterinary use.

Target Fungal

Research area Infection Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

VT-1598 structure

CAS No.: 2089320-99-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 450.00	BP-01970-10mg	In stock	Get quote
25 mg	USD 800.00	BP-01970-25mg	In stock	Get quote
50 mg	USD 1,250.00	BP-01970-50mg	In stock	Get quote
100 mg	USD 1,850.00	BP-01970-100mg	In stock	Get quote
250 mg	Inquire	BP-01970-250mg	In stock	Inquire
1 g	Inquire	BP-01970-1g	Inquire	Inquire

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Description

VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris. VT-1598 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological activity

In Vitro VT-1598 (0.015-8 μg/mL; 24 h) demonstrates in vitro activity against C. auris. VT-1598 (0.03125-0.125 μg/mL; 24 h) shows highly effects in inhibiting the in vitro growth of clinical Candida isolates. In Vivo VT-1598 (oral gavage; 5, 15, and 50 mg/kg; once daily; 7 d) treatment shows a significant and dose-dependent survival advantage, and dose-dependent reductions in fungal burden. VT-1598 (oral gavage; 3.2, 8, and 20 mg/kg; once daily; 4 d) is present to a great extent in the plasma and tongue after oral administration in Act1-deficient mice infected with C. albicans.

Identifiers

SMILES: FC(F)(C1=CC=C(C=N1)C#CC2=CC=C(C=C2)OCC3=CC=C(C=C3)C#N)[C@@](O)(C4=C(C=C(C=C4)F)F)CN5C=NN=N5
InChIKey: UDGASIIGNCBLSI-PMERELPUSA-N

Specifications

MW (average): 584.5231
Formula: C₃₁H₂₀F₄N₆O₂
CAS No.: 2089320-99-8
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1]. Nathan P Wiederhold, et al. The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02233-18.

[2]. Timothy J Break, et al. VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice. J Antimicrob Chemother. 2018 Aug 1;73(8):2089-2094.

Same target

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