(R)-JQ1 Acid free base

(R)-JQ-1 carboxylic acid, is an isomer of JQ-1 carboxylic acid .

For research use only. Not for human or veterinary use.

Target Drug Isomer Epigenetic Reader Domain PD-1/PD-L1

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

(R)-JQ1 Acid structure

CAS No.: 202592-24-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 589.00	BP-02519-500mg	In stock	Get quote
1 g	USD 898.00	BP-02519-1g	In stock	Get quote
5 g	USD 2,998.00	BP-02519-5g	In stock	Get quote
10 g	Inquire	BP-02519-10g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

(R)-JQ-1 carboxylic acid, is an isomer of JQ-1 carboxylic acid . JQ-1 carboxylic acid, a (+)-JQ-1 derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4.

Biological activity

In Vitro JQ-1 carboxylic acid downregulates PD-L1 expression on the surface of B16F10 cells.

Identifiers

SMILES: ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[C@@H]4CC(O)=O)C=C1
InChIKey: LJOSBOOJFIRCSO-CQSZACIVSA-N

Specifications

MW (average): 400.8820
Formula: C₁₉H₁₇ClN₄O₂S
CAS No.: 202592-24-3
Physical state: Solid
Color: Pale-yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1].Huang Y, et, al. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation. Bioconjug Chem. 2022 Jan 19;33(1):142-151.

[2].Chen W, et, al. Dual drugs decorated bacteria irradiate deep hypoxic tumor and arouse strong immune responses. Biomaterials. 2022 Jul;286:121582.

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