CU-CPT-9a free base

CU-CPT-9a is a specific TLR8 antagonist.

For research use only. Not for human or veterinary use.

Target Toll-like Receptor (TLR)

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

CU-CPT-9a structure

CAS No.: 2165340-32-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 420.00	BP-01979-250mg	In stock	Get quote
500 mg	USD 685.00	BP-01979-500mg	In stock	Get quote
1 g	USD 985.00	BP-01979-1g	In stock	Get quote
5 g	Inquire	BP-01979-5g	Inquire	Inquire

Need another size or custom synthesis? Request a quote.

Description

CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.

Biological activity

In Vitro CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF and IRF3 (cytoplasmic and nuclear) are only responsive to TLR4 and TLR3, independent of TLR837. The expression levels of TRIF and IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m and CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases.

Identifiers

SMILES: COC1=CC=C2C(=C1)N=CC=C2C1=CC(C)=C(O)C=C1
InChIKey: HNYBTVKYLVLWCB-UHFFFAOYSA-N

Specifications

MW (average): 265.3065
Formula: C₁₇H₁₅NO₂
CAS No.: 2165340-32-7
Physical state: Solid
Color: light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64.

Same target

Search Toll-like Receptor (TLR)

Same research area

Search Inflammation/Immunology