GW870086 free base · Synonyms: AXR-159
GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist.
For research use only. Not for human or veterinary use.
GW870086 structure
CAS No.: 827319-43-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 460.00 | BP-02087-100mg | In stock | Get quote |
| 250 mg | USD 920.00 | BP-02087-250mg | In stock | Get quote |
| 500 mg | USD 1,470.00 | BP-02087-500mg | In stock | Get quote |
| 1 g | USD 2,360.00 | BP-02087-1g | In stock | Get quote |
| 2 g | USD 3,770.00 | BP-02087-2g | In stock | Get quote |
| 3 g | USD 4,520.00 | BP-02087-3g | In stock | Get quote |
| 5 g | Inquire | BP-02087-5g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC50 of 10.1 in A549 cells expressing NF-κB.
Biological activity
In Vitro GW-870086 a glucocorticoid receptor agonist, inhibits NFkB reporter gene with a pIC50 of 10.1, but shows no effect on the MMTV reporter genes in A549 cells, and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor or androgen receptor. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2)[1]. GW-870086 (GW870086X; 10-100 nM) significantly increases fibronectin secretion. However, GW-870086 has no effect on MMP2 secretion, and does not increase cellular myocilin.
Identifiers
- SMILES
-
[H][C@@]12C[C@@H](C)[C@](OC(=O)C3C(C)(C)C3(C)C)(C(=O)OCC#N)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C - InChIKey
-
WUBKGTSFJSEIEM-NSHBDUGJSA-N
Specifications
- MW (average)
- 559.6413
- Formula
- C31H39F2NO6
- CAS No.
- 827319-43-7
- Physical state
- Solid
- Color
- white to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO