Orismilast free base · Synonyms: LEO-32731
Orismilast (LEO-32731) is an orally active and selective PDE4 inhibitor used for the research of inflammatory diseases.
For research use only. Not for human or veterinary use.
Orismilast structure
CAS No.: 1353546-86-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 580.00 | BP-01457-100mg | In stock | Get quote |
| 250 mg | USD 1,160.00 | BP-01457-250mg | In stock | Get quote |
| 500 mg | USD 1,850.00 | BP-01457-500mg | In stock | Get quote |
| 1 g | USD 3,000.00 | BP-01457-1g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
Orismilast (LEO-32731) is an orally active and selective PDE4 inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants .
Biological activity
In Vitro Orismilast inhibits tumour necrosis factor α (TNFα), and the secretion of T-helper (Th)1 (TNFα and IFNγ), Th17 (IL-22 and IL-23), and Th2 (IL-4, IL-5, and IL-13) related cytokines in PBMC. In Vivo Orismilast (10 and 30mg/kg) significantly reduces ear thickness and inflammation markers (p<0.0001, respectively).
Identifiers
- SMILES
-
O=S1(CCC2(OC3=C(C=CC(C(CC4=C(C=[N+](C=C4Cl)[O-])Cl)=O)=C3O2)OC(F)F)CC1)=O - InChIKey
-
ZININGNRPUGNSL-UHFFFAOYSA-N
Specifications
- MW (average)
- 510.2930
- Formula
- C19H15Cl2F2NO7S
- CAS No.
- 1353546-86-7
- Physical state
- Solid
- Color
- white to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder 4℃ 2 year; In solvent -20℃ 1 month;
Solubility
soluble in DMSO