PDE9-IN-(S)-C33 free base
-C33 is a potent and selective PDE9 inhibitor.
For research use only. Not for human or veterinary use.
Target
Phosphodiesterase (PDE)
Research area
Neurological Disease
Purity >98%
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PDE9-IN-(S)-C33 structure
CAS No.: 2066488-39-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 340.00 | BP-02421-100mg | In stock | Get quote |
| 250 mg | USD 680.00 | BP-02421-250mg | In stock | Get quote |
| 500 mg | USD 1,090.00 | BP-02421-500mg | In stock | Get quote |
| 1 g | USD 1,740.00 | BP-02421-1g | In stock | Get quote |
| 2 g | USD 2,785.00 | BP-02421-2g | In stock | Get quote |
| 3 g | USD 3,340.00 | BP-02421-3g | In stock | Get quote |
| 5 g | Inquire | BP-02421-5g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
(S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research .
Biological activity
In Vitro (S)-C33 shows the T1/2 values of 105 and 54 minutes in human and mouse microsomes.
Identifiers
- SMILES
-
O=C1C2=C(N(C3CCCC3)N=C2)N=C(N[C@H](C4=CC=C(Cl)C=C4)C)N1 - InChIKey
-
FIUCLBJMUGCQTF-NSHDSACASA-N
Specifications
- MW (average)
- 357.8370
- Formula
- C18H20ClN5O
- CAS No.
- 2066488-39-7
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- In solvent -20°C, 1 year
Solubility
Soluble in DMSO : 100 mg/mL
Documents
References
[1].Huang M, Shao Y, Hou J, et al. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol Pharmacol. 2015;88(5):836-845.