NEO-811 free base · Synonyms: NEO 811 · NEO811

NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader.

For research use only. Not for human or veterinary use.

Target Molecular Glues HIF/HIF Prolyl-Hydroxylase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

NEO-811 structure

CAS No.: 3084635-77-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
5 mg	USD 1,896.00	BP-02285-5mg	In stock	Get quote
10 mg	USD 2,985.00	BP-02285-10mg	In stock	Get quote
25 mg	USD 4,952.00	BP-02285-25mg	In stock	Get quote
50 mg	USD 8,662.00	BP-02285-50mg	In stock	Get quote

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Description

NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader. NEO-811 is mediated by CRL4-CRBN E3 ligase for ARNT degradation. NEO-811 can be used for the study of clear cell renal cell carcinoma (ccRCC) .

Biological activity

In Vitro NEO-811 is highly selective and does not degrade well-known neosubstrates. Transcriptomic profiling of NEO-811 activity across several VHL-deficient ccRCC cell lines confirmed suppression of HIF-2α target genes, including cyclin D and vascular endothelial growth factor (VEGF). NEO-811 also uniquely suppresses expression of target genes regulated by other Class I bHLH-PAS transcription factors, including HIF-1α and aryl hydrocarbon receptor (AHR). NEO-811 retaines activity in HIF-2α inhibitor-resistant cells that harbored previously described mutations

Identifiers

SMILES: O=C1CCC(C2=CN=C(C=CC([C@@]3(O)CCN(CC4=CC=C(C5=NOC=N5)C=C4)CC3(C)C)=C6F)C6=C2)C(N1)=O
InChIKey: OFTSSWWYMRYXIM-LOGQOBJBSA-N

Specifications

MW (average): 543.5887
Formula: C₃₀H₃₀FN₅O₄
CAS No.: 3084635-77-5
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Solubility

soluble in DMSO

Documents

References

[1]. Jennifer Griffin, et al. Abstract 6734: Discovery and optimization of NEO-811, a first-in-class molecular glue degrader of ARNT, utilizing structure-based drug design. Cancer Res (2026) 86 (7_Supplement): 6734.

[2]. J. Scott Lee, et al. Abstract 5791: Preclinical characterization of NEO-811, a novel molecular glue degrader of ARNT for the treatment of clear cell renal cell carcinoma. Cancer Res (2026) 86 (7_Supplement): 5791.

Same target

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