Sovilnesib free base · Synonyms: AMG650 | AMG-650

Sovilnesib is a potent, orally active kinesin-like protein KIF18A inhibitor.

For research use only. Not for human or veterinary use.

Target Kinesin Microtubule/Tubulin

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Sovilnesib structure

CAS No.: 2410796-79-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 680.00	BP-02008-1g	In stock	Get quote
5 g	USD 2,720.00	BP-02008-5g	In stock	Get quote
10 g	Inquire	BP-02008-10g	Inquire	Inquire

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Description

Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 μM. Sovilnesib can be used for the research of cancer.

Biological activity

In Vitro Sovilnesib (AMG 650; 0-10 pM; 96 and 144 h; cancer cell lines) has anti-proliferative activity and inhibits tumor cell growth in a dose-dependent manner. In Vivo Sovilnesib (AMG 650; 10-100 mg/kg; p.o. daily, for 45 d; female nude mice without thymus with OVCAR-3 xenografts) inhibits tumor growth, Lasting tumor regression and cure occurred in 50% of the animals, Sovilnesib has no apparent toxicity.

Identifiers

SMILES: CC1=CC(NC(C2=C(N3CCC4(CC3)CC4)C=C(NS(=O)(CCO)=O)C=C2)=O)=NC(N5CCC(F)(F)CC5)=N1
InChIKey: KBDGEJDIHZDPHN-UHFFFAOYSA-N

Specifications

MW (average): 564.6480
Formula: C₂₆H₃₄F₂N₆O₄S
CAS No.: 2410796-79-9
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 100 mg/mL

Documents

References

[1]. Payton MN, et, al. Kif18a inhibitors for treatment of neoplastic diseases. WO2021211549

[2]. Tamayo NA, et, al. Kif18a inhibitors. WO2020132648.

Same target

Search Kinesin

Same research area

Search Cancer