CNDAC hydrochloride salt form · hydrochloride · Parent CNDAC hydrochloride

CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine , and a nucleoside analog.

For research use only. Not for human or veterinary use.

Target Nucleoside Antimetabolite/Analog Drug MetaboliteApoptosis DNA/RNA Synthesis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

CNDAC hydrochloride structure

CAS No.: 134665-72-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 698.00	BP-02503A-50mg	In stock	Get quote
100 mg	USD 1,398.00	BP-02503A-100mg	In stock	Get quote
250 mg	USD 2,268.00	BP-02503A-250mg	In stock	Get quote
500 mg	Inquire	BP-02503A-500mg	In stock	Inquire
1 g	Inquire	BP-02503A-1g	In stock	Inquire

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Description

CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine , and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis .

Biological activity

CNDAC hydrochloride is a metabolite of Sapacitabine, and it is a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis. CNDAC (20mg/kg; i.p.; daily for 10 days) greatly increased the survival time and survival rate in CDF1 mice P388 tumor model.

Identifiers

SMILES: Cl[H].NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1C#N
InChIKey: PKGUOXDXRLGZBN-KUAPJGQRSA-N

Specifications

MW (average): 288.6880
Formula: C₁₀H₁₃ClN₄O₄
CAS No.: 134665-72-8
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, sealed storage, away from moisture

Solubility

Soluble in DMSO

Documents

References

[1]. Liu XJ, et al. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer. 2012 Aug;31(8):373-80.

[2]. Jagan S, et al. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Adv Hematol. 2012;2012:727683.

[3]. Serova M, et al. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells. Br J Cancer. 2007 Sep 3;97(5):628-36.

[4]. Azuma A, et al. Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum. J Med Chem. 1993 Dec 24;36(26):4183-9.

Same target

Search Nucleoside Antimetabolite/Analog

Same research area

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