NCGC00029283 free base · Synonyms: NCGC-00029283 · NCGC 00029283

NCGC00029283 is a novel inhibitor of the werner syndrome helicase-nuclease helicase.

For research use only. Not for human or veterinary use.

Target DNA/RNA Synthesis

Research area Cancer

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Data Sheet SDS COA

NCGC00029283 structure

CAS No.: 714240-31-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 485.00	BP-02227-1g	In stock	Get quote
100 mg	USD 635.00	BP-02227-5g	In stock	Get quote
250 mg	USD 1,085.00	BP-02227-250mg	In stock	Get quote
500 mg	USD 1,365.00	BP-02227-500mg	In stock	Get quote

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Description

NCGC00029283 is a novel inhibitor of the werner syndrome helicase-nuclease (wrn) helicase.

Biological activity

In Vitro NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells

Identifiers

SMILES: O=C1NC2=C(C=C(OC)C=C2)C=C1C3=NOC(C4=CC=C(F)C=C4)=N3
InChIKey: FJQADEHMIMENRE-UHFFFAOYSA-N

Specifications

MW (average): 337.3046
Formula: C₁₈H₁₂FN₃O₃
CAS No.: 714240-31-0
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 6.94 mg/mL

In vitro: DMSO : 6.94 mg/mL

Documents

References

[1]. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525.

Same target

Search DNA/RNA Synthesis

Same research area

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