Quarfloxin free base · Synonyms: Itarnafloxin | CX 3543

Quarfloxin is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells.

For research use only. Not for human or veterinary use.

Target DNA/RNA Synthesis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Quarfloxin structure

CAS No.: 865311-47-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 470.00	BP-02091-25mg	In stock	Get quote
50 mg	USD 680.00	BP-02091-50mg	In stock	Get quote
100 mg	USD 930.00	BP-02091-100mg	In stock	Get quote
250 mg	USD 2,180.00	BP-02091-250mg	In stock	Get quote
500 mg	USD 3,400.00	BP-02091-500mg	In stock	Get quote
1 g	Inquire	BP-02091-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

Quarfloxin is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.

Biological activity

In Vitro Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines. Solution in vitro: Quarfloxin is suspended in DMSO to a stock of 10 mM.

Identifiers

SMILES: O=C1C2=C3N(C=C1C(NCC[C@@H]4CCCN4C)=O)C5=CC6=CC=CC=C6C=C5OC3=C(N7CC(C8=NC=CN=C8)CC7)C(F)=C2
InChIKey: WOQIDNWTQOYDLF-CGAIIQECSA-N

Specifications

MW (average): 604.6733
Formula: C₃₅H₃₃FN₆O₃
CAS No.: 865311-47-3
Physical state: Solid
Color: light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 5 mg/mL (8.27 mM; Need ultrasonic; Dissolution under acidic conditions (HCl adjust to pH ≈3; hygroscopic DMSO has a significant impact on product solubility, please use newly opened DMSO)

Documents

References

[1]. Hald ØH, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12.

Same target

Search DNA/RNA Synthesis

Same research area

Search Cancer